FORSKNING
Videnskablig evidens
Introduktion
Tarmbakterier påvirker vores psyke og sundhed på måder, vi kun langsomt er ved at forstå.
Tarmmikrobiomet er som en galakse: kolossalt, komplekst og bestående af et astronomisk antal mikrober, der interagerer med deres vært. Har det også, som forskning antyder, afgørende betydning for vores mentale og fysiske sundhed? Svaret på det spørgsmål kan blive vigtigt i kampen mod folkesygdomme og psykiske lidelser i fremtiden, siger professor Oluf Borbye Pedersen i denne samtale i en del af Informations naturvidenskabelige serie.
Serien er skrevet af Dagbladet Information journalister Mikkel Vuorela og Johanne Pontoppidan Tuxen, og den er oplæst af Rasmus Bo Sørensen. ’Vi fortæller naturvidenskaben forfra’ er støttet af Carlsbergfondet.
Vores modeller og algoritmer har vi udviklet baseret på en lang række videnskablige forskningsresultater.
De forskerer og eksperter som rådgiver GENEX følger løbende med i de seneste forskningsresultater for at sikre, at vi er på forkant med nye opdagelser som kan hjælpe vores brugerer.
Herunder er et kort uddrag af videnskablige artikler som ligger til grund for vores modeller:
- HLA-DQ typing in the diagnosis of celiac disease
- Genetics of Celiac Disease
- HLA-DQA1 and HLA-DQB1 genetic markers and clinical presentations in celiac disease
- A genetic test which can be used to diagnose adult-type hypolactasia in children
- Prevalence of adult-type hypolactasia as diagnosed with genetic and lactose hydrogen breath tests in Hungarians
- Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre
- Coffee, CYP1A2 genotype, and risk of myocardial infarction
- CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension
- Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension
- Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol on coronary heart disease risk in the Second Northwick Park Heart Study
- Alcohol consumption, alcohol dehydrogenase and risk of coronary heart disease in the MONICA/KORA-Augsburg cohort 1994/1995-2002
- Influence of alcohol dehydrogenase 1C polymorphism on the alcohol – cardiovascular disease association (from the Framingham Offspring Study)
- Role of metabolic polymorphisms NAT2 and CYP1A2 on urinary mutagenicity after a pan-fried hamburger meal
- The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjects
- Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer.
- Polymorphisms of the vitamin D receptor gene and stress fractures
- The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with the vitamin D receptor genotype
- Calcium and vitamin D intake interactions with genetic variants on bone phenotype.
- Methylenetetrahydrofolate reductase 677C-->T genotype modulates homocysteine responses to a folate-rich diet or a low dose folic acid supplement: a randomised control trial
- 5,10-methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women
- Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies
- Il6 gene promoter polymorphism (-174G/C) influences the associations between fat mass and cardiovascular risk factors
- The ability of fish oil to suppress tumour necrosis factor a production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumour necrosis factor a production
- Effect of marine-derived n-3 polyunsaturated fatty acids on C-reactive protein, interleukin 6 and tumour necrosis factor a: a meta-analysis
- TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women
- ADRB2 haplotype is associated with glucose tolerance and insulin sensitivity in obese postmenopausal women
- Influence of the ACE gene insertion/deletion polymorphism on insulin sensitivity and impaired glucose tolerance in healthy subjects
- Association between fat intake, physical activity and mortality depending on genetic variation in FTO
- A high intake of saturated fat strengthens the association between the fat mass and obesity-associated gene
- Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction
- IL6 (-174) and TNFA (-308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise.
- A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males.
- Genetic variation and exercise-induced muscle damage: implications for athletic performance, injury and ageing.
- Familial aggregation of stroke volume and cardiac output during submaximal exercise: the HERITAGE Family Study
- Polymorphisms of the vascular endothelial growth factor gene (VEGF) and aerobic performance in athletes
- Does genetic variation in PPARGC1A affect exercise-induced changes in ventilatory thresholds and metabolic syndrome?
- A genetic-based algorithm for personalized resistance training.
- ACTN3 genotype is associated with human elite athletic performance
- Effective utilization of genetic information for athletes and coaches: focus on ACTN3 R577X polymorphism
- PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men
- The COL1A1 gene and acute soft tissue ruptures.
- Variants within the COL5A1 gene are associated with Achilles tendinopathy in two populations
- Components of the transforming growth factor-B family and the pathogenesis of human Achilles tendon pathology – a genetic association study